Toxicological Profile for Benzene

Toxicological Profile for Benzene

ADDENDUM TO THE TOXICOLOGICAL PROFILE FOR BENZENE Agency for Toxic Substances and Disease Registry Division of Toxicology and Human Health Sciences

Risk assessment of leukaemia and occupational exposure to benzene.

Experimental toxicological studies have offered clear evidence that benzene induces haematopoietic neoplasms, and it is generally accepted that exposure to benzene is a risk factor for leukaemia, in particular for acute non-lymphatic leukaemia. Quantitative aspects of benzene risk assessment are still a matter of controversy, however. In several risk assessments an estimated 50 deaths from leuk...

Toxicological profile of the aqueous-fermented extract of Musa paradisiaca in rats

Objective: This study was conducted to assess the toxicity profile of the aqueous-fermented extract of Musa paradisiaca in rats. Materials and Methods: In acute toxicity test, the rats of different groups were orally administered with a single dose of 500, 1000, 2000 and 5000 mg/kg of fermented extract of M. paradisiaca. The rats were monitored for behavioral changes, toxicity signs and mortali...

Evaluating bioactive constituents and toxicological effects of aqueous extract of fermented Pentaclethra macrophylla seeds in rats

Objective: This study aimed at evaluating the bioactive constituents and the toxicological profile of the aqueous fermented seed extract of P. macrophylla. Material and Methods: The chemical constituents of fermented P. macrophylla were assessed using GC-MS. For acute toxicity study, one-time doses of up to 5000 mg/kg of the extract were...